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Gastrointestinal stromal tumor

1 OMIM reference -
5 associated genes
18 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1

Cutaneous mastocytoma

1 associated gene
11 signs/symptoms

Gastrointestinal stromal tumor

Cutaneous mastocytoma

KIT	(UniProt - OMIM)		KIT	(UniProt - OMIM)
PDGFRA	(UniProt - OMIM)
SDHA	(UniProt - OMIM)
SDHB	(UniProt - OMIM)
SDHC	(UniProt - OMIM)


COMMON GENES	KIT


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	PDGFRA	(0.63)	KIT

Citations in the biomedical literature:

Gastrointestinal stromal tumor		Cutaneous mastocytoma
	Synonym(s): - GIST		Synonym(s): - Cutaneous local mastocytoma - Multiple mastocytoma - Solitary mastocytoma

	Classification (Orphanet): - Rare gastroenterologic disease - Rare genetic disease - Rare oncologic disease		Classification (Orphanet): - Rare allergic disease - Rare hematologic disease - Rare oncologic disease - Rare skin disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: adulthood Average age of death: - Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: normal Type of inheritance: sporadic

	External references: 1 OMIM reference - 1 MeSH reference: D046152		External references: No OMIM references 1 MeSH reference: D054705

Gastrointestinal stromal tumor		Cutaneous mastocytoma
	Very frequent - Estomach / gastric neoplasm / tumor / carcinoma / cancer - Sarcoma Frequent - Asthenia / fatigue / weakness - Constipation - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Intestinal obstruction / ileus - Intestinal perforation - Nausea / vomiting / regurgitation / merycism / hyperemesis Occasional - Anaemia - Colon neoplasm / tumor / carcinoma / cancer - Cutaneous rash - Digestive neoplasm / tumor / carcinoma / cancer - Esophageal neoplasm / tumor / carcinoma / cancer - Hepatitis / icterus / cholestasis - Irregular / in bands / reticular skin hyperpigmentation - Rectum / rectal neoplasm / tumor / carcinoma / cancer - Small bowel neoplasm / tumor / carcinoma / cancer		Very frequent - Abnormal pigmentary skin changes / skin pigmentation anomalies - Macules - Mastocytosis - Pruritus / itching - Subcutaneous nodules / lipomas / tumefaction / swelling - Urticaria - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Frequent - Thick skin / pachydermia / orange skin Occasional - Acute abdominal pain / colic - Facial pain / cephalalgia / migraine - Hot flushes / sensation of cold